Renal Effects of Human α-Atrial Natriuretic Polypeptide
- 30 May 1985
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 312 (22) , 1456-1457
- https://doi.org/10.1056/nejm198505303122213
Abstract
To the Editor: Human α-atrial natriuretic polypeptide (α-hANP) is a potent vasoactive and natriuretic peptide that was recently identified in human atrial extract.1 Although α-hANP is involved in fluid and electrolyte balance in dogs and rats,2 , 3 its action in human beings has not been well defined. After we confirmed that no acute or chronic toxic changes were observed in rats or mice, we investigated the effects of α-hANP on renal function in healthy human subjects.To obtain adequate urine flow, physiologic saline was continuously infused at a rate of 0.2 ml per kilogram of body weight per minute into three . . .Keywords
This publication has 3 references indexed in Scilit:
- Renal effects of a sythetic α-human atrial natriuretic polypeptide (α-hANP) in anesthetized dogsEuropean Journal of Pharmacology, 1984
- Purification and complete amino acid sequence of α-human atrial natriuretic polypeptide (α-hANP)Biochemical and Biophysical Research Communications, 1984
- Effects of atrial natriuretic factor on renal handling of water and electrolytes in ratsCanadian Journal of Physiology and Pharmacology, 1983