Serum Inhibitory Factors in Cancer
- 1 January 1974
- journal article
- Published by S. Karger AG in Oncology
- Vol. 29 (3) , 219-226
- https://doi.org/10.1159/000224903
Abstract
The cellular response and serum blocking factors of 70 cancer patients were assessed by micro-MLC and PHA-stimulation techniques. Serum level of carcinoembryonic antigen (CEA) was determined by radioimmunoassay, and an attempt was made to correlate the concentration of CEA with the inhibitory effect of each serum on the blastogenic response of lymphocytes from cancer and healthy subjects. A direct correlation was found between the serum inhibitory activity, the CEA level and the extent of the disease. However, CEA negative cancer sera also inhibited transformation of autologous and normal homologous lymphocytes. This indicates that circulating CEA does not account for serum blocking activity.Keywords
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