Studies on Hyperproteinemia and Proteinuria in Rats Bearing a Mammosomatotropic Tumor1

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Abstract
Rats bearing mammosomatotropic tumor MTTW5 developed hyperproteinuria coincident with tumor growth. Proteinuria, accompanied by minimal renal morphological changes, was associated with hyperproteinemia and a fall in hematocrit. The electrophoretic pattern of urinary protein from tumor-bearing rats closely resembled serum. The proteinuria and hyperproteinemia ceased following adrenalectomy or tumor resection. Adrenalectomized rats with low protein excretion did not show restoration of hyperproteinuria following the administration of cortisol or desoxycorticosterone. Administration of aldosterone to adrenalectomized tumor-bearing rats caused a slight increase in urinary protein. Although MtTW5 produces excess growth hormone and prolactin, these hormones failed to produce proteinuria in normal rats. MtTW5 does not make excess ACTH. Proteinuria was accompanied by hypercholesterolemia and normal serum Na, K, Cl and urea N.