Synthesis of some dibasic sulphur-containing amino-acids related to L-lysine

Abstract
S-2-Aminoethyl-L-cysteine (thialysine), its Nω-methyl derivative, and S-2-aminoethyl-L-homocysteine have been prepared from the parent sulphur-containing α-amino-acids L-cysteine and L-homocysteine. The thiol amino-acids were condensed with NO-ditosylethanolamine and NO-ditosyl-N-methylethanolamine, to give Nω-tosyl derivatives, from which the protective Nω-tosyl group was removed by reduction with sodium in liquid ammonia.

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