Multiple Subunits of the Caenorhabditis elegans Anaphase-Promoting Complex Are Required for Chromosome Segregation During Meiosis I
Open Access
- 1 February 2002
- journal article
- research article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 160 (2) , 805-813
- https://doi.org/10.1093/genetics/160.2.805
Abstract
Two genes, originally identified in genetic screens for Caenorhabditis elegans mutants that arrest in metaphase of meiosis I, prove to encode subunits of the anaphase-promoting complex or cyclosome (APC/C). RNA interference studies reveal that these and other APC/C subunits are essential for the segregation of chromosomal homologs during meiosis I. Further, chromosome segregation during meiosis I requires APC/C functions in addition to the release of sister chromatid cohesion.Keywords
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