USE OF PROPHYLACTIC PARTIAL EXCHANGE TRANSFUSION IN PREGNANCIES ASSOCIATED WITH SICKLE-CELL HEMOGLOBINOPATHIES

  • 1 January 1976
    • journal article
    • research article
    • Vol. 48  (5) , 516-520
Abstract
Sickle cell anemia is associated with an alarming attrition rate during pregnancy. The maternal morbidity rate, perinatal wastage rate and the incidence of severe morbidity in both mother and child are elevated above acceptable limits. In most cases, these statistics were compiled using conservative therapeutic modalities. The protocol involves the introduction of 750-1000 cm of buffy coat, poor washed red cells exchanged with 1000-1500 cm whole blood during phlebotomy at 28 wk gestation and again prior to term. Thirty-six consecutive pregnant patients with sickle cell anemia were managed in this fashion. The one maternal mortality occurred in a patient who did not complete the protocol. Major maternal morbidity and perinatal wastage rates were significantly decreased. Two cases of serum hepatitis occurred. The use of prophylactic partial exchange transfusion in pregnant patients with severe sickle cell hemoglobinopathies is probably of benefit.

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