Passive Immunization of Mice with Monoclonal Antibodies to Glycoprotein gB of Herpes Simplex Virus

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Abstract
To investigate the protective ability of monoclonal antibodies (MCA) to viral glycoprotein in herpes simplex virus (HSV) infection, athymic nude mice were inoculated intracutaneously with HSV type-1 (HSV-1) in the midflank. Three hours after inoculation, 1 group of mice was passively immunized with 1 of a series of MCA to glycoprotein gB of HSV-1, and a control group of mice was given phosphate buffered saline alone. The control mice died within 16 days after infection; the mice passively immunized with any of the MCA showed suppressed development of skin lesions. Three of 6 mice given MCA failed to develop any visible lesions and no HSV could be isolated from the lumbar dorsal root ganglia of these mice 60 days after the challenge. BALB/c mice were also protected from infection with HSV type 2 by passive immunization with MCA to HSV-1 gB.

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