Degradation of Nucleic Acids and their Related Compounds by Microbial Enzymes

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Abstract
The distribution in microorganisms of extracellular enzymes which degrade DNA into deoxymononucleotides was studied. The degradation products of DNA were determined by using 5′-nucleotidase and prostatic nonspecific phosphomonoesterase. It was found that except Bacillus subtilis IFO 3302, the microorganisms which produced the enzymes that catalyze the degradation of RNA into 5′-mononucleotides, produced the enzymes capable of hydrolyzing DNA into 5′-deoxymononucleotides, whereas the microorganisms which produced such enzymes that degrade RNA into 3′-mononuclcotides did not generally produce the enzymes which hydrolyze DNA.

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