Studies on Antitumor Substances. V. Reaction of Thiosulfonates with Active Methylene Compounds.

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Abstract
The reactions of benzyl benzene or p-tohienethiosulfonate with active methylene compounds were studied to elucidate the mechanism of anti-tumor activity of the analogous pentamethylene bismethanethiosulfonate with the expectation that any alkylation might occur. Benzene or p-toluenethiosulfonate did not benzylate the active methylene compounds but 1 or 2 benzylthio groups were introduced. In the cases of less active methylene compounds, the reaction of thiosulfonates themselves occurred.

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