Study of Renal Vessels by Microdissection in Human Transplantation

Publisher Website
Google Scholar
Abstract
The transplanted kidney of seven patients who survived 9, 25, 26, 28, 33, 126, and 544 days was examined by microdissection of the nephron and the renal arterial tree. In two cases epithelial necrosis was seen in the first part of the proximal convoluted tubule. The desquamated cells had been shed into the lumen and passed down the tubule. In six cases evidence of hypertrophy of the intima and degeneration of media with aneurysmal dilatation could be demonstrated in the interlobular and arcuate arteries and occasionally in the branches from the interlobar artery. Microdissection demonstrates the extreme focal and progressive nature of the disease. The evidence here suggests that the shorter the period of time after transplantation the more likely will the more peripheral vessels be affected, and the longer the period of time the more likely are the larger vessels to be affected. It is suggested that the arterial lesion probably occurs earlier in the syndrome than has previously been described.