Effect of Metal Ions on Brain Peptidase Activity.

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Abstract
The effect of Ca++, Mg++, Cu++, Zn++, Cd++, Co++, Mn++, MoO4, Ni++, Fe+++ and Al+++ was studied on the enzymatic hydrolysis, by cerebral peptidases, of glycyl-L-leucine and glycyl-diglycine. The inhibition was shown to be of different orders of magnitude for different metals. Only cobalt ions were shown to enhance the hydrolysis of glycyl-diglycine by promoting the hydrolysis of the diglycine residue in the tripeptide which normally resists hydrolysis. This effect was specific for diglycine and not applicable to the other N-glycyl dipeptides which are normally not hydrolyzed by brain.

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