Studies on Absorption and Excretion of Drug. VII. A New Estimation Method for the Release of Drugs from Dosage Forms and the Availability in vivo.

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Abstract
The convolution equation was introduced to estimate a drug release from various dosage forms in the gut[image]. From the application of the equation, the drug release in vivo F(t) was calculated from comparison of blood level or urinary excertion of drug and/or the metabolites between the ingestions of a dosage form, X(t), and the dissolved solution, G(t). The evidence of merits of this method and the deviation of the results from the real value caused by the approximation for numerical calculation were investigated by means of a theoretical model. The actual sulfamethylthiadiazole release from the tablet in human gut was estimated from the urinary excretion by using this calculation method also.