The KCNQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3
Open Access
- 6 November 1998
- journal article
- Published by Wiley in FEBS Letters
- Vol. 438 (3) , 171-176
- https://doi.org/10.1016/s0014-5793(98)01296-4
Abstract
Benign familial neonatal convulsions, an autosomal dominant epilepsy of newborns, are linked to mutations affecting two six‐transmembrane potassium channels, KCNQ2 and KCNQ3. We isolated four splice variants of KCNQ2 in human brain. Two forms generate, after transient expression in COS cells, a potassium‐selective current similar to the KCNQ1 current. L‐735,821, a benzodiazepine molecule which inhibits the KCNQ1 channel activity (EC50=0.08 μM), also blocks KCNQ2 currents (EC50=1.5 μM). Using in situ hybridization, KCNQ2 and KCNQ3 have been localized within the central nervous system, in which they are expressed in the same areas, mainly in the hippocampus, the neocortex and the cerebellar cortex. During brain development, KCNQ3 is expressed later than KCNQ2.Keywords
This publication has 23 references indexed in Scilit:
- A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy familyNature Genetics, 1998
- A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newbornsNature Genetics, 1998
- Diversity of Potassium Channels Contributing to Differences in Brain Area‐specific Seizure Susceptibility: Sensitivity of Different Potassium Channels to the Epileptogenic Agent PentylenetetrazolEuropean Journal of Neuroscience, 1997
- A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndromeNature Genetics, 1997
- Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channelNature, 1996
- KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium currentNature, 1996
- Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmiasNature Genetics, 1996
- Developmental expression of voltage‐sensitive K+ channels in mouse skeletal muscle and C2C12 cellsFEBS Letters, 1992
- Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brainNeuron, 1990
- Analogies and differences in the mode of action and properties of binding sites (localization and mutual interactions) of two K+ channel toxins, MCD peptide and dendrotoxin IBrain Research, 1989