Healing‐over in rat crystalline lens.

Publisher Website
Google Scholar
Abstract
1. 42K efflux has been studied in normal and injured rat crystalline lenses to test their ability to heal over. Following injury, a sizeable, but transient, increase in fractional loss of 42K takes place. 2. The lens healing‐over is Ca‐dependent and cannot be accounted for by membrane resealing. This is excluded by the fact that Procion Yellow gains access to damaged fibres even 2 hr after injury (when the healing‐over is completed). 3. The occlusion of the junctional channels is the basic mechanism of healing‐over. This is supported by the observation that Procion Yellow does not diffuse from damaged to intact fibres and by the Ca dependency of the phenomenon.