Kinetic effects of high pressure in congested and strained molecular systems. A useful application of high pressure in organic synthesis
- 1 January 1993
- journal article
- research article
- Published by Taylor & Francis in High Pressure Research
- Vol. 11 (1) , 21-32
- https://doi.org/10.1080/08957959208201689
Abstract
Steric congestion of reaction centers produces late transition states in organic reactions. Intrusion of steric hindrance induces a stronger pressure acceleration. Some relevant examples are given: Menshutkin, Wittig, Michael, Henry reactions, cycloadditions. The pressure parameter is, therefore, of high value in the synthesis of crowded molecules via sterically demanding reactions.Keywords
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