Effects of Gestational Age, Birth Weight, and Hypoxemia on Pharmacokinetics of Amikacin in Serum of Infants
- 1 June 1977
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 11 (6) , 1027-1032
- https://doi.org/10.1128/aac.11.6.1027
Abstract
The serum pharmacokinetics of amikacin were studied in 36 infants treated for suspected bacterial infection. A prolonged serum half-life was associated with the related variables of birth at an early gestational age, low birth weight, and hypoxemia. A postnatal age effect was not apparent when hypoxemic infants were excluded.Keywords
This publication has 27 references indexed in Scilit:
- Renal function in respiratory distress syndromeThe Journal of Pediatrics, 1976
- Age-dependent dose response to gentamicinThe Journal of Pediatrics, 1975
- Amikacin therapy of infections in neutropenic patientsThe Lancet Healthy Longevity, 1975
- Glomerular filtration rate in the first three weeks of lifeThe Journal of Pediatrics, 1975
- Comparative Activity of Tobramycin, Amikacin, and Gentamicin Alone and with Carbenicillin Against Pseudomonas aeruginosaAntimicrobial Agents and Chemotherapy, 1974
- Emergence of Resistance of Providencia stuartii to Multiple Antibiotics: Speciation and Biochemical Characterization of ProvidenciaThe Journal of Infectious Diseases, 1974
- Pharmacology of Gentamicin in ManThe Journal of Infectious Diseases, 1971
- THE EVOLUTION AND SPREAD OF GENTAMICIN-RESISTANT PSEUDOMONADSPublished by Wolters Kluwer Health ,1971
- Clinical assessment of gestational age in the newborn infantThe Journal of Pediatrics, 1970
- Effects of Low Oxygen and of Carbon Monoxide on the Renal Circulation in Unanesthetized RabbitsCirculation Research, 1963