Studies on the Organization of the Human Apolipoprotein B100 Gene
- 1 January 1987
- journal article
- research article
- Published by Walter de Gruyter GmbH in Biological Chemistry Hoppe-Seyler
- Vol. 368 (1) , 419-426
- https://doi.org/10.1515/bchm3.1987.368.1.419
Abstract
The organization of five exons of the 3'' terminal end of the human apolipoprotein B 100 (apo B 100) gene 1906, 184, 115, 7572 and 374 bp long have been determined from two overlapping EMBL3 human genomic clones extending over 18 kb. They encode more than 70% of the apo B 100 amino-acid sequence. The introns between these five exons were sequenced revealing the common intron/exon splice junction sequences. The 7572 bp exon is the longest exon so far reported for mammalian genes with the proposed sequence coding for the LDL receptor binding site. Its posible relationship to apolipoprotein B 48 is discussed.This publication has 24 references indexed in Scilit:
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