Distal sites of action of diuretic drugs in the dog nephron
- 30 June 1968
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 215 (1) , 228-235
- https://doi.org/10.1152/ajplegacy.1968.215.1.228
Abstract
Renal micropuncture experiments during antidiuresis and water diuresis in the dog demonstrated that the osmolality of distal tubular fluid was always increased after the administration of chlormerodrin, chlorothiazide, furosemide, and perhaps acetazolamide. These findings suggest strongly that the site of action of each of these drugs must at least include one or more portions of the ascending limb of Henle''s loop.This publication has 4 references indexed in Scilit:
- Micropuncture study of bicarbonate reabsorption by the dog nephronAmerican Journal of Physiology-Legacy Content, 1968
- Micropuncture study of the proximal and distal tubule in the dogAmerican Journal of Physiology-Legacy Content, 1967
- Micropuncture study of the effect of various diuretics on sodium reabsorption by the proximal tubules of the dog.Journal of Clinical Investigation, 1966
- The Site of Action of Furosemide and Other Sulfonamide Diuretics in the Dog*Journal of Clinical Investigation, 1965