Evidence for a new tumour suppressor locus (DBM) in human B–cell neoplasia telomeric to the retinoblastoma gene
- 1 January 1993
- journal article
- Published by Springer Nature in Nature Genetics
- Vol. 3 (1) , 67-72
- https://doi.org/10.1038/ng0193-67
Abstract
Roughly 25% of human B-cell chronic lymphocytic leukaemias (CLL) are characterized by a chromosomal lesion involving 13q14. This region contains the retinoblastoma gene (RB1). We have used a variety of techniques to determine whether RB1 or some other locus is the critical region in 11 cases of low grade B-cell malignancy (mainly CLL), all with deletions or translocations involving 13q14. In all cases, except the one with minimal disease, there was deletion or a structural lesion in the region of D13S25, with at least 4 cases showing homozygous disruption. We conclude that D13S25 lies close to a tumour suppressor locus whose inactivation contributes to the initiation or progression of low grade B-cell malignancy. This locus is located at least 530 kilobases telomeric to RB1.Keywords
This publication has 24 references indexed in Scilit:
- Retinoblastoma gene deletions in b‐cell chronic lymphocytic leukemiaGenes, Chromosomes and Cancer, 1992
- Molecular Definition of Interstitial Deletions of Chromosome 13 in Leukemic CellsGenes, Chromosomes and Cancer, 1991
- Hemizygous deletion of the 3′ end of the RB1 gene in a case of Philadelphia positive-acute lymphoblastic leukemiaCancer Genetics and Cytogenetics, 1991
- Tumor suppressor genesCell, 1991
- Report of the committee on the genetic constitution of chromosome 13Cytogenetic and Genome Research, 1991
- A physical map around the retinoblastoma geneGenomics, 1990
- Prediction of the Risk of Hereditary Retinoblastoma, Using DNA Polymorphisms within the Retinoblastoma GeneNew England Journal of Medicine, 1988
- Clonal chromosome abnormalities in chronic lymphocytic leukemia patients revealed by TPA stimulation of whole blood culturesCancer Genetics and Cytogenetics, 1987
- A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcomaNature, 1986
- Simultaneous identification of chromatid replication and of human chromosomes in metaphases of man-mouse somatic cell hybridsCytogenetic and Genome Research, 1977