Drug and gene targeting to the brain with molecular trojan horses
Top Cited Papers
- 1 February 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Drug Discovery
- Vol. 1 (2) , 131-139
- https://doi.org/10.1038/nrd725
Abstract
Getting drugs and genes into the brain is a tall order. This is because the presence of the blood-brain barrier prevents many molecules from crossing into the brain. Overcoming this problem will have a profound effect on the treatment of many neurological disorders, allowing larger water-soluble molecules to pass into the brain. Transport vectors, such as endogenous peptides, modified proteins or peptidomimetic monoclonal antibodies, are one way of tricking the brain into allowing these molecules to pass. This article will review such molecular Trojan Horses, and the progress that has been made in the delivery of drugs and genes to the brain.Keywords
This publication has 54 references indexed in Scilit:
- Neuroprotection in Transient Focal Brain Ischemia After Delayed Intravenous Administration of Brain-Derived Neurotrophic Factor Conjugated to a Blood-Brain Barrier Drug Targeting SystemStroke, 2001
- Aβ1-40 Peptide Radiopharmaceuticals for Brain Amyloid Imaging: 111In Chelation, Conjugation to Poly(ethylene glycol)-Biotin Linkers, and Autoradiography with Alzheimer's Disease Brain SectionsBioconjugate Chemistry, 2000
- Inflammatory responses and their impact on β-galactosidase transgene expression following adenovirus vector delivery to the primate caudate nucleusGene Therapy, 1999
- Epidermal Growth Factor Radiopharmaceuticals: 111In Chelation, Conjugation to a Blood-Brain Barrier Delivery Vector via a Biotin-Polyethylene Linker, Pharacokinetics, and in Vivo Imaging of Experimental Brain TumorsBioconjugate Chemistry, 1999
- Retention of Biologic Activity of Human Epidermal Growth Factor Following Conjugation to a Blood-Brain Barrier Drug Delivery Vector via an Extended Poly(ethylene glycol) LinkerBioconjugate Chemistry, 1998
- Intracerebral injection of adenovirus harboring the HSVtk gene combined with ganciclovir administration: toxicity study in nonhuman primatesGene Therapy, 1998
- Pre-existing herpes simplex virus 1 (HSV-1) immunity decreases, but does not abolish, gene transfer to experimental brain tumors by a HSV-1 vectorGene Therapy, 1998
- Glut1 Glucose Transporter Activity in Human Brain InjuryJournal of Neurotrauma, 1996
- Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia.Stroke, 1991
- Complex tight junctions of epithelial and of endothelial cells in early foetal brainJournal of Neurocytology, 1975