In-vitro activity of fleroxacin compared with three other quinolones

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Abstract
The in-vitro activity of fieroxacin (Ro23-6240), a new synthetic quinolone, was compared with that of three other quinolones against 665 clinical isolates of aerobic bacteria by the agar dilution technique. Fieroxacin showed similar activity to norfloxacin, enoxacin and pefloxacin against most isolates of Enterobacteriaceae, Neisseria meningitidis, N. gonorrhoeae ,Haemophilis influenzae,Staphylococcus spp. and Streptococcus faecalis. Fieroxacin was the most active quinolone against Enterobacter spp. Fieroxacin was not as active against Pseudomonas aeruginosa, but the MIC90 (4 mg/1) is still below the reported peak serum level after a standard oral dose of 400 mg.

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