THE HUMAN MALE CYCLE OF URINARY OESTRONE AND 17-OXOSTEROIDS

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Abstract
SUMMARY: A study has been made of the amounts of oestrone excreted in the urine on alternate days and of the daily excretion of creatinine, 17-oxosteroids, and 17-hydroxycorticosteroids of one homosexual and four normal men. The results suggest an 8- to 10-day cycle of urinary oestrone and 17-oxosteroids excretion. Although the cyclical change is small it is statistically significant. The cyclical activity is interpreted to be of testicular origin and suggests the possibility of a sexual cycle in the human male. Sexual cycles of male animals are discussed, and the human male cyclic period compared with that of the human menstrual cycle. A similar rhythmic period of feedback between the gonads and the nervous system in males and females is suggested.

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