Fusion of Mass Spectrometry-Based Metabolomics Data
Top Cited Papers
- 17 September 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 77 (20) , 6729-6736
- https://doi.org/10.1021/ac051080y
Abstract
A general method is presented for combining mass spectrometry-based metabolomics data. Such data are becoming more and more abundant, and proper tools for fusing these types of data sets are needed. Fusion of metabolomics data leads to a comprehensive view on the metabolome of an organism or biological system. The ideas presented draw upon established techniques in data analysis. Hence, they are also widely applicable to other types of X-omics data provided there is a proper pretreatment of the data. These issues are discussed using a real-life metabolomics data set from a microbial fermentation process.Keywords
This publication has 22 references indexed in Scilit:
- Towards replacing closed with open target selection strategiesTrends in Biotechnology, 2005
- Exploiting biological complexity for strain improvement through systems biologyNature Biotechnology, 2004
- Observing and interpreting correlations in metabolomic networksBioinformatics, 2003
- Fusion of aroma, FT-IR and UV sensor data based on the Bayesian inference. Application to the discrimination of white grape varietiesChemometrics and Intelligent Laboratory Systems, 2002
- Life's Complexity PyramidScience, 2002
- Systems Biology: A Brief OverviewScience, 2002
- Metabolomics – the link between genotypes and phenotypesPlant Molecular Biology, 2002
- Integrated Genomic and Proteomic Analyses of a Systematically Perturbed Metabolic NetworkScience, 2001
- Variable and subset selection in PLS regressionChemometrics and Intelligent Laboratory Systems, 2001
- Identification of Uncommon Plant Metabolites Based on Calculation of Elemental Compositions Using Gas Chromatography and Quadrupole Mass SpectrometryAnalytical Chemistry, 2000