Influence of Citalopram and Chlorimipramine on Uptake of 5‐HT by Isolated Perfused Guinea Pig Lungs

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Abstract
A method is described for the preparation and perfusion in vitro of isolated guinea pig lungs. 5‐HT is rapidly taken up from a perfusing solution by this organ (about 70% uptake). In the concentration range 10‐7 to 5 × 10‐6 M citalopram concentration dependently inhibited the uptake of 5‐HT by the lung preparation. Chlorimipramine inhibited the uptake of 5‐HT only by 40–50%, and the inhibition was not concentration dependent. The method used seems to be a reliable model for studying the uptake of 5‐HT.