Stereospecific 6-alkylation of oestradiol derivatives via Cr(CO)3 complexes
- 1 January 1984
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 7,p. 428-429
- https://doi.org/10.1039/c39840000428
Abstract
The increased kinetic acidity of benzylic hydrogen atoms of aromatic steroids temporarily modified by the Cr(CO)3 group provides access to 6-alkylated oestradiol derivatives with controlled stereochemistry; the relative binding affinities of these modified hormones with receptor to the oestradiol respect have been measured.Keywords
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