Benzodiazepine mediated antagonism of opioid analgesia
- 1 May 1997
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Pain
- Vol. 71 (1) , 25-29
- https://doi.org/10.1016/s0304-3959(97)03332-0
Abstract
Activation of supraspinal γ-aminobutyric acid-A (GABAA) receptors is known to result in antagonism of opioid analgesia. Since benzodiazepines enhance the action of GABA at GABAA receptors, we hypothesized that administration of these agents for preoperative sedation might antagonize the analKeywords
This publication has 0 references indexed in Scilit: