trans-2,3b,4,5,7,8b,9,10-Octahydronaphtho[1,2-c:5,6-c']dipyrazole, a new orally active antiallergic compound

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Abstract
The synthesis and anti-allergic activity of a new heterocyclic steroidal molecule were described. The compound reaction inhibited the rat passive cutaneous anaphylaxis reaction and its activity in this system was compared to that of disodium cromoglycate. It was orally active at a dose of 35 mg/kg (ED50) and its activity persisted for up to 6 h at larger doses.