Inhibition of protein prenylation by patulin
- 22 February 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 318 (1) , 88-90
- https://doi.org/10.1016/0014-5793(93)81334-v
Abstract
The antibiotic patulin was found to inhibit protein prenylation in mouse FM3A cells. Thus, the agent reduced incorporation of [3H]mevalonate into proteins by 50% at a concentration of 7 microM. In a cell-free assay, patulin inhibited rat brain farnesyl:protein transferase, one of the enzymes responsible for protein prenylation. The inhibition was 50% at a concentration of 290 microM.Keywords
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