Renal Hypertension

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Abstract
Hypertension produced by experimental renal artery constriction in dogs can be corrected by decreasing renal mass by partial nephrectomy. Application of a restricting, but not constricting, clamp to a renal artery of a dog results in hypertension only after contralateral nephrectomy. It is suggested that renal hypertension can be a result of relative, as well as of absolute, renal ischemia. Compensatory hypertrophy, whether focal or total, increases demand for blood which cannot be met in the face of severe arterial or arteriolar sclerosis. It is further suggested that cure of even long-standing hypertension which results from renal transplantation without removal of the diseased kidney results from removal of the stimulus for compensatory hypertrophy. It is concluded that renal compensatory hypertrophy, whether focal or total, can, under the proper circumstances, be the initiating factor leading to hypertension.

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