ACUTE HEMATOGENOUS STAPHYLOCOCCAL OSTEOMYELITIS - A DESCRIPTION OF THE NATURAL-HISTORY IN AN AVIAN MODEL

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 110  (3) , 333-345
Abstract
A simple and reproducible avian model of acute hematogenous osteomyelitis is described; the natural history of the disease was documented. Infection was induced by i.v. injection of bacteria. Chickens were killed 6, 12, 24, 48, 96 and 192 h following bacterial inoculation; the left proximal tibia and distal femur were removed for histologic examination. Bacterial deposition initially occurred within the growing ends of metaphyseal tunnels in the hypertrophic region of the zone of cartilage transformation in the growth plate. Bacterial proliferation occluded the vascular tunnel within 24 h. The initial deposition of bacteria, the subsequent spread and the nature of the inflammatory process are discussed in relation to the vascular arrangement adjacent to the growth plate. The frequent formation of sequestrum and the effect on the growth plate of an adjacent abscess is described.