Characterization of amphioxus amphivent, an evolutionarily conserved marker for chordate ventral mesoderm
- 10 April 2001
- Vol. 29 (4) , 172-179
- https://doi.org/10.1002/gene.1021
Abstract
Summary: Structure and developmental expression are described for amphioxus AmphiVent, a homolog of vertebrate Vent genes. In amphioxus, AmphiVent-expressing ventral mesoderm arises at midneurula by outgrowth from the paraxial mesoderm, but in vertebrates, Vent-expressing ventral mesoderm originates earlier, at the gastrula stage. In other embryonic tissues (nascent paraxial mesoderm, neural plate, endoderm, and tailbud), AmphiVent and its vertebrate homologs are expressed in similar spatiotemporal domains, indicating conservation of many Vent gene functions during chordate evolution. The ventral mesoderm evidently develops precociously in vertebrates because their relatively large embryos probably require an early and extensive deployment of the mesoderm-derived circulatory system. The vertebrate ventral mesoderm, in spite of its strikingly early advent, still resembles the nascent ventral mesoderm of amphioxus in expressing Vent homologs. This coincidence may indicate that Vent homologs in vertebrates and amphioxus play comparable roles in ventral mesoderm specification. genesis 29:172–179, 2001.Keywords
This publication has 31 references indexed in Scilit:
- Patterning the Early Zebrafish by the Opposing Actions of bozozok and vox/ventDevelopmental Biology, 2000
- Smad1 and Smad4 Are Components of the Bone Morphogenetic Protein-4 (BMP-4)-induced Transcription Complex of the Xvent-2B PromoterJournal of Biological Chemistry, 2000
- Mouse Lbx1 and human LBX1 define a novel mammalian homeo☐ gene family related to the Drosophila lady bird genesMechanisms of Development, 1995
- Barx1, a new mouse homeodomain transcription factor expressed in cranio-facial ectomesenchyme and the stomachMechanisms of Development, 1995
- Landmarks in the anterior central nervous system of amphioxus larvaePhilosophical Transactions Of The Royal Society B-Biological Sciences, 1994
- A Drosophila melanogaster homologue of the T-cell oncogene HOX11 localises to a cluster of homeobox genesGene, 1994
- Homeobox‐containing genes in the most primitive metazoa, the spongesEuropean Journal of Biochemistry, 1994
- PCR Cloning of an Orphan Homeobox Gene (PRH) Preferentially Expressed in Myeloid and Liver CellsBiochemical and Biophysical Research Communications, 1993
- Identification of a different-type homeobox gene, BarH1, possibly causing Bar (B) and Om(1D) mutations in Drosophila.Proceedings of the National Academy of Sciences, 1991
- The embryology of amphioxusJournal of Morphology, 1932