Stat3 and Stat4: members of the family of signal transducers and activators of transcription.
- 24 May 1994
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 91 (11) , 4806-4810
- https://doi.org/10.1073/pnas.91.11.4806
Abstract
The deduced amino acid sequence of two members of the signal transducers and activators of transcription (STAT) family from the mouse are described. Comparison with the deduced protein sequence of the two previously described genes (Stat91 and Stat113), discovered because of their activation as transcription factors after interferon-induced tyrosine phosphorylation, shows several highly conserved regions, including the putative SH3 and SH2 domains. The conserved amino acid stretches likely point to conserved domains that enable these proteins to carry out the several required functions they are known and proposed to carry out. While Stat1 and Stat3 are widely expressed, Stat4 expression is restricted to testis, thymus, and spleen. Antiserum to Stat3 detects a major approximately 92-kDa protein and a minor approximately 89-kDa protein, while antiserum to Stat4 precipitates one major protein of approximately 89 kDa.Keywords
This publication has 21 references indexed in Scilit:
- Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactionsPublished by Elsevier ,1994
- Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteinsNature, 1993
- Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free formsCell, 1993
- Identification of a Ten-Amino Acid Proline-Rich SH3 Binding SiteScience, 1993
- Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.Proceedings of the National Academy of Sciences, 1992
- SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling ProteinsScience, 1991
- Oncogenes and signal transductionCell, 1991
- Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons.Molecular and Cellular Biology, 1991
- Interferon-dependent transcriptional activation: signal transduction without second messenger involvement?1990
- Regulation of Protein Synthesis in Virus-Infected Animal CellsPublished by Elsevier ,1986