MONOCLONAL-ANTIBODIES PROTECT AGAINST RESPIRATORY SYNCYTIAL VIRUS-INFECTION IN MICE

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 52  (1) , 137-142
Abstract
Twenty-five mouse monoclonal antibodies (Mab) to respiratory syncytial virus (RSV) and 2 to hepatitis B virus were inoculated i.v. into mice. The mice were challenged intranasally with RSV 24 h later. Eleven of 14 Mab against fusion protein and 4 of 6 Mab against a larger glycoprotein (GP84) significantly reduced the titer of RSV in the lungs when mice were killed 5 days later. Five Mab against 3 other RSV proteins and 2 Mab against hepatitis B virus had no significant effect on RSV infection. Evidently, serum IgG against 1 epitope on the fusion protein and another on the larger glycoprotein (GP84) will completely protect mice against challenge. These epitopes are primary candidates for an RSV vaccine produced by techniques of gene cloning and peptide synthesis.

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