Mutagenicity of lichen constituents

1 January 1984

journal article
research article
Published by Wiley in Environmental Mutagenesis

Vol. 6 (5) , 757-762
https://doi.org/10.1002/em.2860060512

Abstract

Usnic acid (the most abundant lichen constituents), physodic, and physodalic acids isolated from Hypogymnia enteromorph (Ach.) Nyl. were tested for mutagenicity in the Ames Salmonella/microsome assay. Physodalic acid exhibited clear doserelated mutagenicity against Salmonella typhimurium strain TA100 with or without S9 mix in both plate‐incorporation and preincubation assays. The addition of S9 mix increased the number of revertants approximately threefold and fourfold in preincubation and plate‐incorporation assays, respectively.

Keywords

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