Improved accuracy of multiple ncRNA alignment by incorporating structural information into a MAFFT-based framework
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Open Access
- 25 April 2008
- journal article
- Published by Springer Nature in BMC Bioinformatics
- Vol. 9 (1) , 212
- https://doi.org/10.1186/1471-2105-9-212
Abstract
Structural alignment of RNAs is becoming important, since the discovery of functional non-coding RNAs (ncRNAs). Recent studies, mainly based on various approximations of the Sankoff algorithm, have resulted in considerable improvement in the accuracy of pairwise structural alignment. In contrast, for the cases with more than two sequences, the practical merit of structural alignment remains unclear as compared to traditional sequence-based methods, although the importance of multiple structural alignment is widely recognized.Keywords
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