The Acute Toxicity of Dimethylamides in Several Animal Species

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Abstract
The toxicity of a homologous series of twelve N,N-dimethylamides (Hallcomids) was assessed by the intravenous, intraperitoneal, intragastric, and percutaneous routes in mice and rabbits. The ability of this unique and versatile class of dimethylamides to enhance skin penetration was studied by mixing the compounds with an organophosphorus compound (VX). The toxicity of the Hallcomids was compared with the toxicity of other common dimethyl compounds (dimethylsulfolane, dimethylacetamide, dimethylformamide, dimethylsulfoxide). It was concluded that the Hallcomids are slightly to moderately toxic, and precautions to prevent skin contact should be taken for safe use and handling.

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