Studies on Human Clot Retraction

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Abstract
Dialysis of platelet homogenates removes material needed for clot retraction. Platelet homogenates, platelet dialysate and serotonin possess clot retraction potentialities. Plasma also contains material concerned with clot retraction and, when it is adsorbed with barium carbonate, it loses clot retraction activity. This activity, which is adsorbed on barium carbonate, can be eluted with dilute sodium citrate solutions. The adsorbed factor(s) is believed to be a protein. Thus, a plasma protein and dialyzable platelet substance(s), which includes serotonin, are concerned with clot retraction. Even in low concentration, glycerol interferes with clot retraction, and clots that do not retract are invariably transparent. Submitted on August 6, 1956