Plasma-CSF Glycine Ratio in Normal and Nonketotic Hyperglycinemic Subjects

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Abstract
To the Editor: The report by Perry and his colleagues1 on glycine metabolism in brain and cerebrospinal fluid of patients with various types of hyperglycinemia highlights an important general theme — namely, the relation of amino acid concentrations in cerebrospinal fluid to the metabolism of amino acids in brain.Cerebrospinal fluid is apparently cleared of amino acids by up-take on specific membrane transport systems at the brain-cerebrospinal-fluid interface.2 , 3 It is believed that amino acids appear in the fluid largely by efflux from brain.4 In this sense, filtration and reabsorption of amino acids in kidney are analogous to the flux of . . .

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