Autoradiographic localization of thyrotropin‐releasing hormone receptors in amyotrophic lateral sclerosis spinal cord

1 November 1985

journal article
Published by Wolters Kluwer Health in Neurology

Vol. 35 (11) , 1650
https://doi.org/10.1212/wnl.35.11.1650

Abstract

We used quantitative autoradiography to determine the density of thyrotropin-releasing hormone (TRH) receptors in discrete regions of spinal cord from four Datients with amvotrophic lateral sclerosis (ALS). The density and distribution of [³H]-3-methyl-histidine¹-TRH binding to TRH receptors differed from reported values in normal individuals, with fewer TRH receptors in lamina II and lamina IX. The diminished concentration of TRH receptors in lamina IX may reflect the loss of motor neurons in ALS.

Keywords

LAMINA
SUP
TRH
RECEPTORS
THYROTROPIN
HORMONE
SPINAL
CORD
LATERAL

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