A proposal for a three-dimensional aetiologic view of the schizophrenias. I

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Abstract
There is an absence of empirical evidence to support the current clinical subdivisions of the schizophrenias. However, research has provided evidence for regarding schizophrenia as a heterogeneous group of diseases. This article puts forward a view of the aetiology which tries to combine the evidence from studies of genetics, brain damage, and psychosocial factors in a three-dimensional model. These factors may act in concert, or one or two of them may dominate. Such a view makes it possible to understand some of the difficulties in clinical research, since the prognosis, therapeutic goals, and methods regarding the subtypes may be different and even opposite. This may eliminate possible effects in an unselected group of schizophrenic patients.

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