Oxygen Tensions in Normal and Ischemic Tissues During Hyperbaric Therapy

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Abstract
The maintenance of adequate tissue oxygenation becomes an overwhelming problem in the presence of certain disease and traumatic states. Various cardiovascular, pulmonary, bacterial, and toxic conditions imperil the normal flow of oxygen to the tissue and can threaten the survival of organ systems and life itself. In the presence of severe trauma with disruption of circulation, loss of life or limb may occur unless there is rapid restoration of tissue oxygenation. There has recently been considerable interest in the use of hyperbaric oxygen as a means of improving oxygen tensions in normal and diseased tissues. This present study was an attempt to quantitate changes in oxygen tensions during hyperbaric therapy in normal tissues and in tissues with an inadequate blood supply. It is our feeling that with basic, experimental studies of this type the uses and limitations of hyperbaric oxygen therapy will be better understood. Methods Studies were performed on

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