Stimulation of Prostaglandin Release by Ca2⊕-Mobilizing Agents from the Perfused Rat Liver. A Comparative Study on the Action of ATP, UTP, Phenylephrine, Vasopressin and Nerve Stimulation
- 1 January 1988
- journal article
- research article
- Published by Walter de Gruyter GmbH in Biological Chemistry Hoppe-Seyler
- Vol. 369 (1) , 65-68
- https://doi.org/10.1515/bchm3.1988.369.1.65
Abstract
Several Ca2+-mobilizing agents were tested for their potential to elicit the net release of prostaglandins from the isolated perfused rat liver. Among these ATP and UTP only led to an efficient stimulation of PGD2 and PGE2 synthesis. 20.mu.M ATP or 20.mu.M UTP increased the release of PGD2 8-fold and that of PGE2 2 to 3-fold. In total, at least 40 times more PGD2 than PGE2 left the liver after stimulation. The time course of prostaglandin release was similar for both nucleotides. Vasopressin had almost no effect on the release of both prostaglandins and on portal vein pressure. But phenylephrine and nerve stimulation while raising the PGD2 efflux only slightly caused an elevation of PGE2 outflow and portal pressure.This publication has 18 references indexed in Scilit:
- Studies on synthesis and degradation of eicosanoids by rat hepatocytes in primary cultureJournal of Hepatology, 1987
- Prostaglandin Responses in Isolated Perfused Rat Liver: Ca2⊕and K⊕Fluxes, Hemodynamic and Metabolic EffectsBiological Chemistry Hoppe-Seyler, 1987
- Metabolism of prostaglandins D2 and F2α in primary cultures of rat hepatocytesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986
- Characterization of responses of isolated rat hepatocytes to ATP and ADP.Journal of Biological Chemistry, 1985
- Elastase in the different primary granules of the human neutrophilBiochemical and Biophysical Research Communications, 1985
- Stimulation of hepatic glycogenolysis by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) via cyclooxygenase productsBiochemical and Biophysical Research Communications, 1985
- Degradation of Prostaglandin E2 in a Primary Culture of Adult Rat Hepatocytes1The Journal of Biochemistry, 1984
- On the Mechanisms of ATP-Induced and Succinate-Induced Redistribution of Cations in Isolated Rat Liver CellsEuropean Journal of Biochemistry, 1983
- Involvement of Prostaglandin E and Adenosine 3′ 5′‐Monophosphate in Lipopolysaccharide‐Stimulated Collagenase Release by Rat Kupffer CellsEuropean Journal of Biochemistry, 1982
- Direct Control of Glycogen Metabolism in the Perfused Rat Liver by the Sympathetic InnervationEuropean Journal of Biochemistry, 1982