Evaluation of the stimulatory capacity of procaine on Na transport through frog skin

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Abstract
Procaine has different effects on various ionic conductive pathways through the frog skin. We investigated the season and temperature dependence of the stimulation by mucosal procaine, of the Na-conductive pathway. For this stimulation, we found higher half-maximal saturation constants (KNa) in winter animals (6.38 +/- 0.8 mmol/l), than in summer ones (4.03 +/- 0.7 mmol/l). Summer frogs kept for 2 weeks at 4 degrees C, reacted like winter frogs (6.24 +/- 0.8 mmol/l). However, the maximal sodium currents (INa max) did not depend on temperature adaptation. Procaine-induced increased of KNa is associated with an increase of INa. The effects of procaine associated with BIG (benzoylimidazole-2-guanidine) were non-additive, while with vasopressin they were additive. A biphasic, dose-dependent response was recorded after procaine application to the inner surface. Vasopressin counteracted the serosal procaine-induced inhibition of the Na-transport.

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