Aromatic esters of 5-O-desosaminylerythronolide A oxime
- 1 August 1975
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 18 (8) , 849-851
- https://doi.org/10.1021/jm00242a020
Abstract
Several substituted aromatic esters of the C-3 hydroxyl of 5-O-desosaminylerythronolide A oxime were prepared. Ribosomal binding studies showed that meta substituents on the aromatic ring gave the most active analogs. The esters described were all inactive in vivo at the maximum level tested.Keywords
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