Factors which disorganize microtubules or microfilaments increase the frequency of cell transformation by polyoma virus

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Abstract
Griseofulvin, 12-O-tetradecanoyl phorbol-13-acetate, melittin, epidermal growth factor, vinblastine, cytochalasin B, podophyllotoxin, colcemid and colchicine were unable to transform cells but could increase from 8- to 40-fold the frequency of [mouse primary kidney] cell transformation by polyoma virus. The 3T3-like cells were resting at confluence and were exposed to the drug only during the 1st wk after viral infection. Griseofulvin, a tumor promoter, reduced or increased the frequency of transformation depending on the dose with which the infected cells were treated. The antitumor activity of tumor promoters is discussed.