Serum Collagen-Like Protein in Patients with Chronic Liver Disease

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Abstract
The method of hot trichloroacetic acid extraction was proved to be simple and reliable for the determination of serum collagen-like protein. Serum collagen-like protein behaved as a macromolecular form by a gel filtration analysis and migrated electrophoretically in the β∼γ-globulin region. Serum levels of collagen-like protein increased in chronic liver disease, especially in chronic active hepatitis. Serum levels of collagen-like protein did not correlate to the morphological grade of hepatic fibrosis. Studies on biopsy liver specimens, labelled with 14C proline in vitro, could not confirm but might suggest that the specific radioactivities of hepatic collagen reflected serum levels of collagen-like protein.

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