A Simple Synthesis ofC-Glucosides Related to the Antitumor Agent Etoposide
- 1 March 1993
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 12 (2) , 209-222
- https://doi.org/10.1080/07328309308021271
Abstract
The synthesis of four new lignan derivatives 2a, 2b, 3a and 3b related to the anticancer agent etoposide has been accomplished. In these compounds a methylene or ethylene group of a C-glucoside separates the glucosidic moiety as present in etoposide (1) from its lignan aglycone bonded by an ethereal function. The key step in the synthesis involves the reaction of a benzylated alditol 4 or 5 and the unprotected 4′-demethylepipodophyllotoxin (6).Keywords
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