Emergence of New HIV-1 Subtypes Other Than Subtype C among Antenatal Women in Lusaka, Zambia
- 20 May 2001
- journal article
- research article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 17 (8) , 759-763
- https://doi.org/10.1089/088922201750237031
Abstract
Molecular epidemiology of HIV-1 in Zambia was investigated by direct sequencing of PCR products from samples collected from antenatal attendees in Lusaka, Zambia. One hundred and forty samples were initially screened for HIV, using antibody assays. Thirty-three (23.6%) samples were HIV-1 positive. Sequences of the HIV-1 env gp120 region were obtained from 28 of 33 (85%) HIV-1-positive samples. Twenty-six of the 28 sequences were HIV-1 env subtype C-like as previously reported. However, one HIV-1 env subtype D-like virus and one HIV-1 env subtype G-like virus were identified. This is the first time that these two HIV-1 env subtype viruses have been identified in Zambia, suggesting that more subtypes could be in existence.Keywords
This publication has 25 references indexed in Scilit:
- A chimpanzee rhadinovirus sequence related to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8: increased detection after HIV-1 infection in the absence of diseaseAIDS, 2000
- HIV-1 Subtype C in Commercial Sex Workers in Addis Ababa, EthiopiaJAIDS Journal of Acquired Immune Deficiency Syndromes, 2000
- Simplified Strategy for Detection of Recombinant Human Immunodeficiency Virus Type 1 Group M Isolates by gag/env Heteroduplex Mobility AssayJournal of Virology, 2000
- Multiple sites in HIV-1 reverse transcriptase associated with virological response to combination therapyAIDS, 2000
- A Predominantly HIV Type 1 Subtype C-Restricted Epidemic in South African Urban PopulationsAIDS Research and Human Retroviruses, 1999
- HIV Type 1 V3 Serotyping of Tanzanian Samples: Probable Reasons for Mismatching with Genetic SubtypingAIDS Research and Human Retroviruses, 1998
- Geographical distribution of HIV-1 group O viruses in AfricaAIDS, 1997
- CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceNucleic Acids Research, 1994
- V3 Loops of HIV-1 Specimens from Pregnant Women in Malawi Uniformly Lack a Potential N-Linked Glycosylation SiteAIDS Research and Human Retroviruses, 1993
- Specificity and Function of the Individual Amino Acids of an Important Determinant of Human Immunodeficiency Virus Type 1 that Induces Neutralizing ActivityJournal of General Virology, 1989