Simulation of depolarization in a membrane-equations-based model of the anisotropic ventricle
- 1 July 1998
- journal article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Biomedical Engineering
- Vol. 45 (7) , 847-855
- https://doi.org/10.1109/10.686792
Abstract
The results of a simulation study of the propagation of depolarization in inhomogeneous anisotropic (monodomain) myocardial tissue are presented. Simulations are based on modified Beeler-Reuter membrane equations, and performed on a block of anisotropic myocardium with rotating fiber geometry, measuring 1 cm x 1 cm x 0.3 cm, at various levels of spatial discretization (0.15 mm, 0.30 mm, 0.60 mm). At a discretization level of 0.6 mm the algorithm allowed the simulation in a realistically shaped model of the ventricle, including rotational anisotropy, as well. For this simulation results are justified by comparing results for the block at various levels of discretization, for which the surface to volume ratio has been adjusted. By placing the model ventricle in a realistically shaped (human) volume conductor model, realistic body surface potentials (QRST waveforms) are simulated.Keywords
This publication has 13 references indexed in Scilit:
- A Hybrid Model of Propagated Excitation in the Ventricular MyocardiumPublished by Springer Nature ,1996
- A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes.Circulation Research, 1994
- Computer simulations of three-dimensional propagation in ventricular myocardium. Effects of intramural fiber rotation and inhomogeneous conductivity on epicardial activation.Circulation Research, 1993
- Spreading of excitation in 3-d models of the anisotropic cardiac tissue. I. validation of the eikonal modelMathematical Biosciences, 1993
- Description of cardiac sources in anisotropic cardiac muscleJournal of Electrocardiology, 1992
- Computer model of excitation and recovery in the anisotropic myocardiumJournal of Electrocardiology, 1991
- The effect of torso inhomogeneities on body surface potentials quantified using “tailored” geometryJournal of Electrocardiology, 1989
- Revised formulation of the Hodgkin-Huxley representation of the sodium current in cardiac cellsComputers and Biomedical Research, 1987
- A Practical Algorithm for Solving Dynamic Membrane EquationsIEEE Transactions on Biomedical Engineering, 1978
- Total Excitation of the Isolated Human HeartCirculation, 1970