Chlormethiazole, sleep, and drug withdrawal
- 1 August 1972
- journal article
- research article
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 2 (3) , 239-247
- https://doi.org/10.1017/s0033291700042537
Abstract
Synopsis: The hypothesis that drug withdrawal delirium was related to a gross disturbance of sleep and a marked excess of REM sleep, suggested that drugs used to treat delirium should depress REM sleep. Chlormethiazole in doses over l g was found to be effective in depressing REM sleep and in blocking the REM sleep rebound when sodium amylobarbitone (400 mg) was stopped abruptly.Keywords
This publication has 20 references indexed in Scilit:
- Sleep and Hypnotics: Further ExperimentsBMJ, 1970
- Differential effects of chlorpromazine and phenobarbital on EEG sleep patternsJournal of Psychiatric Research, 1969
- Chlormethiazole and Trifluoperazine in Alcohol WithdrawalThe British Journal of Psychiatry, 1969
- Sleep and Barbiturates: some Experiments and ObservationsBMJ, 1968
- Mental activity during sleep: Recall studies, somnambulism, and effects of rapid eye movement deprivation and drugsExperimental Neurology, 1967
- EFFECT OF CHLORMETHIAZOLE UPON THE CLINICAL COURSE OF ALCOHOLIC DELIRIUMActa Psychiatrica Scandinavica, 1966
- THE FIRST NIGHT EFFECT: AN EEG STUDYOF SLEEPPsychophysiology, 1966
- Controlled Trial of Chlormethiazole in Treatment of the Alcoholic Withdrawal PhaseBMJ, 1965
- The Nature and Treatment of Delirium Tremens and Allied ConditionsJournal of Mental Science, 1955
- THE RESULTS OF MEDICINAL TREATMENT IN ELEVEN HUNDRED AND SIS CASES OF DELIRIUM TREMENSThe Lancet Healthy Longevity, 1911